Imipramine is used to treat depression. Some of the medicines that may lead to imipramine interactions include: Alcohol. There are limited data on the use of imipramine in children for other indications. Imipramine may also be used for purposes not listed in this medication guide. Tofranil is a tricyclic antidepressant and brand name of the drug imipramine. If you are prescribed this medication, ensure that your pharmacist and/or doctor shares the following drug interaction safety information: Alcohol: Alcohol increases the sedative effects of this medication. Imipramine zoloft interactions > [email protected] by Start Bootstrap People usually get sick 12 hours to three days after they eat something contaminated. Imipramine hydrochloride is not approved for use in pediatric patients (see WARNINGS, Clinical Worsening and Suicide Risk; PRECAUTIONS, Information for Patients; and PRECAUTIONS, Pediatric Use). Cimetidine interaction with imipramine and nortriptyline. Tricyclic antidepressants such as imipramine work by increasing the amount of norepinephrine and serotonin neurotransmitters (chemical substances in the brain) available in certain parts of the brain. Indications and dose. This study is created by eHealthMe based on reports of 29 people who take Imipramine hydrochloride and Atenolol from Food and Drug Administration (FDA), and is updated regularly. Depressive illness. treatment. It can also increase your risk of a dangerous irregular heart rhythm called QT prolongation. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Drugs that may lead to interactions include anticholinergic medications, barbiturates, blood pressure medications, and cimetidine. Breathing suppression, or trouble breathing. imipramine Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs. Summary: Drug interactions are reported among people who take Imipramine hydrochloride and Clonazepam together. Low price and best customer support! Only Quality tabs. Imipramine is a tricyclic antidepressant. When imipramine tablets or capsules are used to treat depression, they are usually taken one or more times a day and may be taken with or without food. This syndrome was first described during the 1960s in studies of monotherapy and combination therapy Cimetidine, pressors, and alcohol are among the drugs that can potentially interact with imipramine pamoate. The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence. Each drug was administered alone and in combination. Acute Myocardial Infarction Recovery. Taking this medicine with other drugs that make you sleepy can worsen this effect. Imipramine affects chemicals in the brain that may become unbalanced. Other drugs that interact with imipramine include: Cordarone, Nexterone, or Pacerone (amiodarone). See Serotonin syndrome and Monoamine-oxidase inhibitor under Antidepressant drugs for more information and for specific advice on avoiding monoamine-oxidase inhibitors during and after administration of other serotonergic drugs. Imipramine hydrochloride and Gabapentin drug interactions - from FDA reports. Do not stop taking this medicine suddenly as it may cause withdrawal symptoms like mood changes and irritability. imipramine oral Side Effects. Depression. These may occur within a few hours or may take months to develop Nursing Nov 17, 2010 · A potentially lethal condition, serotonin syndrome (SS) is caused most often when certain antidepressant agents are taken concurrently with other drugs that modulate synaptic serotonin levels. Warfarin drug interactions. ourth is that it has strange and bizare interactions with other medicines. Jan 22, 2019 · Tofranil. Imipramine comes as a tablet and a capsule to take by mouth. Dry mouth, blurred vision, headache, drowsiness, dizziness, constipation, nausea, vomiting, loss of appetite, diarrhea, stomach cramps, weight gain/loss, and increased sweating may occur. Additional treatment, hospitalization, or an extended hospital stay may be necessary. Amitriptyline (Elavil, Endep), Clomipramine (Anafranil), Imipramine (Tofranil) Tricyclic antidepressants are metabolized in the body by the enzyme CYP1A2. Imipramine is used to treat symptoms of depression Imipramine is sometimes used to treat bed-wetting in children ages 6 and older. Deaths may occur from overdosage with this class of drugs. Relief of nocturnal enuresis is perhaps due to anticholinergic activity and to nervous system stimulation, resulting in earlier arousal to sensation of full bladder. Johns wort, tryptophan). Includes App for iPhone, iPad, and Android smartphone tablet. Serious side effects include an increased risk of suicidal behavior in those under the age of 25, seizures, mania, and liver problems. Drugs A-Z Pill Identifier Supplements Symptom Checker Diseases Dictionary Media Imipramine is approved by the FDA in children and adolescents 6 years and older for the treatment of nocturnal enuresis and in adolescents for the treatment of major depression. These medicines are thought to work by increasing the activity of a chemical called serotonin in the brain. H. Imipramine is used to treat symptoms of depression. The medication has been approved for treating depression in adults and nocturnal enuresis in children 6 and older. Combining imipramine with phenothiazine medications can increase the level of imipramine in your blood, increasing your risk of side effects. Dont Wean Imipramine alone, work with our Prescription Drug Experts. When imipramine tablets are used to prevent bedwetting in children, they are usually taken one hour before bedtime. Activators: drugs that increase the enzyme’s ability to metabolize the substrates • The table contains lists of drugs in columns under the designation of specific cytochrome P450 isoforms. Drug interactions are reported among people who take Imipramine hydrochloride and Gabapentin together. A healthcare professional should be consulted before taking any drug, Nov 01, 2019 · If you have an allergy to imipramine or any other part of this medicine (imipramine tablets). Cardiovascular Disease. Talpur b Aman Kaushik c Javed H. Imipramine is also used for childhood bedwetting (enuresis) in children ages 6 and older. Tofranil is a tricyclic antidepressant taken orally that is primarily used to treat depression in adolescents and adults. 1 Severity - Major: The effects are potentially life-threatening or capable of causing permanent damage. This eMedTV page describes how drug interactions with imipramine pamoate can alter the levels of some drugs in the blood or cause side effects. An assessment is done once you start the Imipramine Withdrawal Program which allows us to individualize your gameplan based on age; length of time on the medications; health challenges; lifestyle, stress levels; additional medications; and interactions. Imipramine is approved by the FDA in children and adolescents 6 years and older for the treatment of nocturnal enuresis and in adolescents for the treatment of major depression. drug interactions or adverse effects, nor Drug Interactions With Imipramine Hydrochloride. You should also tell your doctor if you have any chest pain or shortness of breath, or if you have any dizziness, headache, WebMD provides information about which foods to avoid while taking Imipramine Oral. Drug Interactions With Imipramine Hydrochloride. Very Important. Initially up to 75 mg daily in divided doses, then increased to 150–200 mg daily, up to 150 mg may be given as a single dose at bedtime, dose to be increased gradually. g. Imipramine zoloft interactions OYes Buy Now! Best choice. Feb 06, 2019 · Rated Imipramine for Attention deficit-hyperactivity disorder (ADHD) Report. Pheochromocytoma. 2 Severity - Moderate: The effects may cause deterioration in a patients clinical status. Imipramine (Tofranil, Tofranil-PM) is an antidepressant medication prescribed for the treatment of depression, bedwetting, and chronic pain. Interactions Imipramine commonly interacts with many other medications. These drug interactions can cause the body to metabolize the drugs differently than intended. If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Norepinephrine: strong reuptake inhibition. Y: Imipramine can help your child control nighttime bed-wetting. Chamomile has been found to inhibit CYP1A2 and may theoretically increase blood concentrations of tricyclic antidepressants, increasing the risk of toxicity. Genetic Implication. S. Acetylcholine: imipramine is an anticholinergic, specifically an antagonist IMIPRAMINE HYDROCHLORIDE. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. There are 21 disease interactions with imipramine: Anticholinergic Effects. Who is eHealthMe: Imipramine Hydrochloride may potentiate the effects of CNS depressant drugs. To view the entire topic, please sign in or purchase a subscription. Imipramine helps to elevate mood and eliminate or reduce other symptoms associated with depression. Tricyclic antidepressants are also prescribed by some clinicians for Imipramine user reviews from around the web. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Drug interactions with imipramine pamoate can alter the levels of some medicines in your blood or cause side effects. An open‐label, three‐way randomized crossover study was done to determine the safety, pharmacokinetics, and potential for a drug interaction between olanzapine (5 mg) and imipramine (75 mg). Lung dysfunction, such as a drop in pH (respiratory acidosis) or development of ventilator failure. Mar 17, 2019 · e. Several small, placebo-controlled studies and open trials have confirmed the panic-blocking effects of this drug; however, many of these studies also employed behavioral therapy, thus obscuring the relative contribution of imipramine. , St. It works by restoring balance to chemicals in the brain that helps regulate mood. Tell your doctor about the allergy and what signs you had, like rash; hives ; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. Sep 09, 2019 · Imipramine drug interactions (in more detail) Further information Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Tell your doctor if you have used an SSRI antidepressant in the past 5 weeks, Jul 16, 2007 · Cytochrome P 450 enzyme interactions. Ambien Drug Interactions. However, the main therapeutic activity is believed to be inhibition of the neuronal re-uptake of noradrenaline and 5HT. D: . Talk to your healthcare provider before taking these medications together. Nov 09, 2018 · Desipramine Interactions. Imipramine affects chemicals in the brain that may be unbalanced in people with depression. U. Y: Imipramine can help your child control nighttime bed-wetting. This study is created by eHealthMe based on reports of 13 people who take Imipramine hydrochloride and Gabapentin from FDA, and is updated regularly. only if the constipation part is removed and the memory part is not affected/compensated in someway , this medicine is a panacea for me. Interactions. Drugs & Medications Imipramine Hcl. Imipramine zoloft interactions | [email protected] by Start Bootstrap People usually get sick 12 hours to three days after they eat something contaminated. Here, Imipramine-AuNPs conjugates were drop-casted on SPEs as described in experimental methods. imipramine oral brand names and other generic formulations include: Deconil Oral, Etnofril Oral, Imavate Oral, Janimine Oral, Norfranil Oral, Sk-Pramine Oral, Tofranil Oral All generic drug interactions for imipramine oral (lists will include brand and generic names): Imipramine is a tricyclic antidepressant. ( epinephrine). Imipramine is an effective medicine, used to treat depression. Jan 23, 2008 · Drug interactions are of concern because the outcome of concurrent drug administration is diminished therapeutic efficacy or increased toxicity of one or more of the administered compounds. Lexapro and Imipramine hydrochloride drug interactions - from FDA reports. In order to quantify the specific interaction of isoniazid with that of imipramine molecules, the vacant gold surfaces were blocked with human serum albumin (HSA) on Imipramine-AuNPs. o. Find user ratings and reviews for imipramine oral on - RxList including side effects and drug interactions, medication effectiveness, ease of use and satisfaction . Drug interactions are reported only by a few people who take Lexapro and Imipramine hydrochloride together. Gold nanoparticles based sensor for in vitro analysis of drug-drug interactions using imipramine and isoniazid drugs: A proof of concept approach Author links open overlay panel Tayyaba Shaikh a b Ashish Pandey a Sirajuddin b Farah N. Other drugs in this class are desipramine (Norpramin), nortriptyline (Pamelor, Aventyl), and imipramine (Tofranil). Patients should be warned that Imipramine Hydrochloride may enhance the CNS depressant effects of alcohol (see WARNINGS). Although Imipramine showed success in treating depression, it also caused a high rate of manic and hypomanic reactions. Imipramine Disease Interactions. Imipramine, with both impaired total metabolic clearance and enhanced bioavailability, in conjunction with increased accumulation of desipramine, would have marked increases in steady-state plasma concentration of both imipramine and desipramine with concurrent cimetidine therapy during chronic p. Acetylcholine: imipramine is an anticholinergic, specifically an antagonist Imipramine is a tricyclic antidepressant. Lamotrigine and Imipramine hydrochloride drug interactions - from FDA reports Summary: Drug interactions are reported only by a few people who take Lamotrigine and Imipramine hydrochloride together. Initially 10 mg daily, increased to 30–50 mg daily, dose to be increased gradually. Imipramine-flupenthixol decanoate interaction. Interactions that increase your risk of side effects. Mechanisms of drug interactions are usually divided into two major categories, pharmacokinetic and pharmacodynamic. Skip to main content. Table 2a and andbb shows the CYP450 enzymes involved in the pathways for inactivation of the TCAs and it is noteworthy that only desipramine and nortriptyline are dependent on only one isoform, CYP2D6, for their inactivation, which is thus more predictable with genetic data. Several of the known interactions with imipramine hydrochloride are related to a potentially dangerous group of symptoms known as serotonin syndrome. It is taken by mouth. The authors describe a case in which flupenthixol decanoate and imipramine were co-administered to a patient with schizophrenia, resulting in extremely high levels of imipramine and its metabolite, desipramine. Imipramine is indicated for therapy of depression and was approved for this indication in the United States in 1959; it is still widely used, with more than 1 million prescriptions being filled yearly. The following are serious effects that may occur when given propofol: Irritation of the skin and veins where the drug was injected. IMIPRAMINE HYDROCHLORIDE. When went from a dose of 50 mg to 75 mg per day. Examples of these drugs include: Anticholinergic drugs, such as diphenhydramine, meclizine, olanzapine, oxybutynin, and tolterodine Taking any of these drugs with imipramine may cause blurred vision, dry eyes, trouble urinating, and nausea. Ask your doctor before taking desipramine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures. Imipramine is sometimes used to treat bed-wetting in children ages 6 and older. Jul 16, 2007 · Cytochrome P 450 enzyme interactions. Starting imipramine in a patient who is being treated with linezolid or IV methylene blue is contraindicated because of an increased risk of serotonin syndrome If linezolid or IV methylene blue must be administered, discontinue imipramine immediately and monitor for CNS toxicity; may resume imipramine 24 hr after last linezolid or methylene blue dose or after 2 weeks of monitoring, whichever comes first Both imipramine and buspirone can increase the risk of serotonin syndrome. Drug interactions are reported among people who take Imipramine hydrochloride and Atenolol together. What you should do about this interaction: Tell your doctor if there is a change in your blood pressure, since he may need to change the dose of your medicine depending on your blood pressure. Interaction between Amitriptyline and Imipramine: There is no known interaction between Amitriptyline Results and discussion. Anticholinergic medications, including: Imipramine Hydrochloride may potentiate the effects of CNS depressant drugs. It belongs to a group of medicines known as tricyclic antidepressants (TCA). Imipramine, sold under the brand name Tofranil among others, is a tricyclic antidepressant (TCA) which is used mainly in the treatment of depression. See Serotonin syndrome and Monoamine-oxidase inhibitor under Antidepressant drugs in BNF for more information and for specific advice on avoiding monoamine-oxidase inhibitors during and after administration of other serotonergic drugs. Ephedra and ephedrine. Dopamine: imipramine blocks D 2 receptors. Epi-Pen, Epi-Pen, Jr. , Canada- fast shipping! Both imipramine and zolmitriptan can increase the risk of serotonin syndrome. Imipramine zoloft interactions Go Buy Now! Best choice. Amitriptyline is in an older class of drugs called tricyclic antidepressants (TCAs), which include some of the earliest medications designed to treat depression. Cimetidine, pressors, and alcohol are among the drugs that can potentially interact with imipramine pamoate. 1,2 When patients take two or more antidepressants from different pharmacologic classes, drug-drug interactions may occur; these interactions may lead to potentially severe serotonin toxicity, or SS. Taking imipramine with other drugs that make you sleepy can worsen this effect. Other possible drug interactions with Ambien may include flumazenil, rifampin, and alcohol. Imipramine tablets are also used to treat enuresis (bedwetting) in children. Imipramine is a tricyclic antidepressant that continues to be widely used in the therapy of depression. Start studying ATI Chapter 50: Adverse Effects, Interactions & Contraindications. Acetylcholine: imipramine is an anticholinergic, specifically an antagonist Jul 16, 2007 · Cytochrome P 450 enzyme interactions. Talk with your healthcare provider before taking these medications together. The literature on the co-administration of neuroleptics and antidepressants is reviewed The mechanisms of imipramines actions include, but are not limited to, effects on: Serotonin: very strong reuptake inhibition. Both sertraline and imipramine can increase the risk of hyponatraemia. Drugs for irregular heartbeat, like Tikosyn (dofetilide), dobutamine, and Betapace or Betapace AF ( sotalol). Make sure to talk with your healthcare provider or pharmacist about the imipramine pamoate drug interactions that may apply to you. Many drugs can interact with imipramine. As a TCA antidepressant, imipramine potentiates the effects of both norepinephrine and serotonin in the CNS by blocking their reuptake by the neurons. It is created by eHealthMe based on reports of 2 people who take the same drugs from FDA, and is updated regularly. beleive me its the most effective antidep . Serious Side Effects and Reactions. Nov 01, 2019 · If you have an allergy to imipramine or any other part of this medicine (imipramine tablets). These drug interactions with imipramine hydrochloride can alter medicine levels in your blood and increase the risk for side effects. It increases the brain effects of alcohol, barbiturates, sedatives, narcotics and anesthetics Imipramine pharmacokinetics serve as a marker for hepatic CYP2D6, CYP1A2, CYP3A activity. A healthcare professional should be consulted before taking any drug, Sep 09, 2019 · Imipramine drug interactions (in more detail) Further information Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Tell your doctor if you have used an SSRI antidepressant in the past 5 weeks, Jan 23, 2008 · Drug interactions are of concern because the outcome of concurrent drug administration is diminished therapeutic efficacy or increased toxicity of one or more of the administered compounds. May include involuntary fine motor tremors, rigidity, uncontrollably restlessness, & acute dystonia (spastic movements and/or muscle rigidity affecting the head, neck, eyes, facial area, & limbs). Imipramine can make certain blood pressure mediations, such as clonidine ( Catapres® ), less effective. Not sure if this was the cause, however I recently began taking the medicine and after a couple of weeks have just begun to experience a burning sensation when I have to urinate. Therapeutic Effects. Amitriptyline vs Imipramine. Both sertraline and imipramine can increase the risk of serotonin syndrome. Davis and Unbound Medicine covers 5000 trade name and generic drugs. T1 - A possible bupropion and imipramine interaction [1] AU - Shad, Mujeeb. Clomipramine. It can also be used to treat bed-wetting in children age six and older It is not considered a controlled substance by the FDA. Both imipramine and lisdexamfetamine can increase the risk of serotonin syndrome. Tagamet (cimetidine). Davis’s Drug Guide for Nurses App Web from F. A. Also, taking it with high blood pressure medications may increase your chance of low blood pressure (hypotension). It is vital that a doctor supervise such combinations to avoid adverse reactions. The most significant risk associated with the use of MAOIs is the potential for drug interactions with over-the-counter and prescription medicines, ‘controlled’ drugs or medications, and some dietary supplements (e. • Definitions. Common side effects include dry mouth, constipation, loss of appetite, sleepiness, weight gain, sexual dysfunction, and trouble urinating. imipramine is a topic covered in the Daviss Drug Guide. Not all possible interactions are listed here. In addition, our data suggest that it is taken for Anxiety, although it is not approved for this condition*. Who is eHealthMe: Imipramine is a tricyclic antidepressant and has several pharmacological actions including alpha-adrenolytic, antihistamine, anticholinergic and 5HT-receptor blocking properties. For example, medications such as imipramine and chlorpromazine may cause an additional decrease of awareness in patients. Monoamine Oxidase Inhibitors (MAOIs): Treatment with this medication should not be IMIPRAMINE (continued) SIDE EFFECTS How Drug Causes Side Effects • Anticholinergic activity may explain sedative effects, dry mouth, constipation, and blurred vision • Sedative effects and weight gain may be due to antihistamine properties • Blockade of alpha adrenergic 1 receptors may explain dizziness, sedation, and hypotension Imipramine may enhance the CNS depressant effects of alcohol. Oral supplementation with SAMe has demonstrated antidepressant activity, independent of its combination with imipramine. This study is created by eHealthMe based on reports of 25 people who take Imipramine hydrochloride and Clonazepam from Food and Drug Administration (FDA), and is updated regularly. ATI Chapter 50: Adverse Effects, Interactions & Contraindications. Inhibitors: drugs that prevent the enzyme from metabolizing the substrates. PY - 1997. You should also tell your doctor if you have any chest pain or shortness of breath, or if you have any dizziness, headache, Drug Interactions With Imipramine Hydrochloride. The literature on the co-administration of neuroleptics and antidepressants is reviewed Imipramine-cimetidine interaction: impairment of clearance and enhanced absolute bioavailability. Imipramine: Interactions Significant interactions with alcohol, barbiturates, cimetidine, neuroleptics (central nervous sedation) and other drugs with anticholinergic effects; with MAO inhibitors, sympathomimetics (hypertensive crisis, general reaction); quinidine (cardiotoxicity). Imipramine is a tricyclic antidepressant and has several pharmacological actions including alpha-adrenolytic, antihistamine, anticholinergic and 5HT-receptor blocking properties. Such symptoms might include: Oral supplementation with SAMe has demonstrated antidepressant activity, independent of its combination with imipramine. Imipramine belongs to a class of medications called tricyclic antidepressants. The mechanisms of imipramines actions include, but are not limited to, effects on: Serotonin: very strong reuptake inhibition. Drug interactions. Niazi a Drug Development and Drug Interactions; Drug Development and Drug Interactions: Possible Models for Decision-Making; Drug Development and Drug Interactions: Table of Substrates, Inhibitors and imipramine, nortriptyline) • Possible interaction with tricyclic antidepressants in the direction of blood levels, but the clinical significance is not established. Imipramine (Tofranil) is a tricyclic antidepressant that was developed in the last 1950s by Ciba-Geigy and is mainly used for major depression and for the inability to control urination. Ask your doctor before taking imipramine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures. Many medicines can cause drug interactions with imipramine hydrochloride, including pressors and cimetidine. Side effects, drug interactions, pregnancy safety, and precautions should be reviewed prior to taking this medication. It was assumed that pretreatment with cimetidine, because of its inhibition of metabolic pathways of both demethylation and hydroxylation as well as its ability to reduce hepatic extraction of these drugs, would increase bioavailability and decrease clearance of both drugs. , Canada- fast shipping! Drug Interactions With Imipramine Hydrochloride. Feb 21, 2018 · Tofranil is a tricyclic antidepressant and brand name of the drug imipramine. Imipramine is prescribed for Depression and is mostly mentioned together with this indication. Y1 - 1997. Learn about drug interactions between lorazepam oral and imipramine pamoate oral and use the RxList drug interaction checker to check drug combinations. Imipramine pharmacokinetics serve as a marker for hepatic CYP2D6, CYP1A2, CYP3A activity. This review analyzes the effectiveness and drug interactions between Lexapro and Imipramine hydrochloride. AU - Preskorn, S. , Canada- fast shipping! Lamictal and Imipramine hydrochloride drug interactions - from FDA reports Summary: Drug interactions are reported only by a few people who take Lamictal and Imipramine hydrochloride together. Will cut back to 50 mg. Imipramine Hydrochloride and Serotonin Syndrome. Imipramine hydrochloride and Gabapentin drug interactions - from FDA reports Drug interactions are reported among people who take Imipramine hydrochloride and Gabapentin together. Substrates: drugs that are metabolized as substrates by the enzyme. It is also effective in treating anxiety and panic disorder . Learn vocabulary, terms, and more with flashcards, games, and other study tools. Imipramine is the most thoroughly studied tricyclic antidepressant for the treatment of agoraphobia and panic disorder. It should be started at lower doses and gradually increased. Name /bks_53161_deglins_md_disk/imipramine 02/14/2014 03:35PM Plate # 0-Composite pg 3 # 3 Canadian drug name. The mechanisms of imipramines actions include, but are not limited to, effects on: Serotonin: very strong reuptake inhibition Norepinephrine: strong reuptake inhibition. Imipramine Withdrawal and Tapering Help. Both imipramine and buspirone can increase the risk of serotonin syndrome. Therefore, it should be borne in mind that the dangers inherent in a suicide attempt or accidental overdosage with the drug may be increased for the patient who uses excessive amounts of alcohol. A healthcare professional should be consulted before taking any drug, Interactions that increase your risk of side effects. This eMedTV page lists other drugs that may cause an imipramine interaction and describes the possible effects that may occur as a resultye, eo, no, hq, oc, ue, th, fo, ty, hn, jr,